Ethyl bromoacetate → HCID 53687702, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 11-7 (355 mg, 1.67 mmol) and THF (10 mL) at −78° C. was added NaN(TMS)2 (1.83 mL, 1.83 mmol, 1.0 M in THF). After 20 min, ethyl bromoacetate (0.203 mL, 1.84 mmol) was added and the reaction was warmed to 0° C. After 30 minutes, the reaction mixture was diluted with EtOAc and then washed with H2O, brine, dried (MgSO4), and concentrated to give 11-8 as a yellow oil.

Provenance & Evidence