Ethyl bromoacetate → HCID 53774644, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 12-3 (210 mg, 0.7257 mmol) and THF (5 mL) at −78° C. was added NaN(TMS)2 (0.943 mL, 0.943 mmol, 1.0 M in THF). After 30 min, ethyl bromoacetate (0.104 mL, 0.9434 mmol) was added and the reaction was warmed to 0° C. After 1.0 hour, the reaction mixture was diluted with EtOAc and then washed with sat NaHCO3, brine, dried (MgSO4), and concentrated to give 12-4 as a yellow oil.

Provenance & Evidence