HCID 53682092, compound → HCID 54145684, compound

HRID 322521Notes

Reaction equation

HRID 322521 reaction equation
[CH2:1]([O:3][C:4](=[O:31])[CH2:5][N:6]1[C@H:10]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:9][C@H:8]([CH2:18][CH2:19][C:20]2[CH:29]=[CH:28][C:27]3[C:22](=[N:23][CH:24]=[CH:25][CH:26]=3)[N:21]=2)[C:7]1=[O:30])[CH3:2].[H][H]>CCO.[Pd].[C]>[CH2:1]([O:3][C:4](=[O:31])[CH2:5][N:6]1[C@H:10]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:9][C@H:8]([CH2:18][CH2:19][C:20]2[CH:29]=[CH:28][C:27]3[CH2:26][CH2:25][CH2:24][NH:23][C:22]=3[N:21]=2)[C:7]1=[O:30])[CH3:2]

Participants

5

Reactant 2

HCID 53682092HCID 53682092, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54145684HCID 54145684, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A mixture of 12-6 (220 mg, 0.5270 mmol) and 10% Pd/carbon (100 mg) in EtOH (4 mL) was stirred under a balloon of hydrogen for 2 h. Following filtration and evaporative removal of the solvent, the residue was chromatographed (silica gel, 70:25:5 chloroform/ethyl acetate/MeOH to give 12-7 as a colorless oil.

Workup

  1. filtrationfiltration
  2. customremoval of the solvent
  3. customthe residue was chromatographed (silica gel, 70:25:5 chloroform/ethyl acetate/MeOH

Sources & evidence

ORD record
ord-4325223a5b8d41ed8e4dd16f8243aeb3
Source dataset
uspto-grants-2001_04
Patent number
US06211184B1

Reaction notes

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