Lithium → HCID 54130332, compound

Participants

Reaction Conditions

Reaction Steps

To a blue solution of lithium metal (0.237 g, 34.2 mmol) in NH3 (1) (200 mL) at −78° C. was added a solution of 13-6 (2.60 g, 8.54 mmol) in THF (15 mL). The mixture was stirred for 15 minutes, then quenched by the addition of ammonium chloride until the blue color dispersed. An additional 30 mL of THF was added, and the mixture warmed to 35° C. to evaporate the ammonia. MgSO4 was added,the mixture was filtered through a celite pad. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 70:20:10 chloroform/ethyl acetate/MeOH) to give 13-7 as a colorless oil.

Provenance & Evidence