Sodium Hydroxide → HCID 22086393, compound

HRID 322527Notes

Reaction equation

HRID 322527 reaction equation
C([O:3][C:4](=[O:21])[CH2:5][N:6]1[C@H:10]([CH3:11])[CH2:9][C@H:8]([NH:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C:7]1=[O:20])C.[OH-].[Na+]>CCO>[C:16]([O:15][C:13]([NH:12][C@H:8]1[CH2:9][C@@H:10]([CH3:11])[N:6]([CH2:5][C:4]([OH:21])=[O:3])[C:7]1=[O:20])=[O:14])([CH3:17])([CH3:18])[CH3:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54537755HCID 54537755, compound

Product 1

HCID 22086393HCID 22086393, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution 13-8 (527 mg, 1.75 mmol) in EtOH was added 1N NaOH (1.93 mL, 1.925 mmol). After stirring for 1 h, the solvents were evaporated, the mixture was diluted with EtOAc, acidified with 10% KHSO4, washed with brine, dried over MgSO4, and evaporated to give 13-9 as a white solid.

Workup

  1. customthe solvents were evaporated
  2. additionthe mixture was diluted with EtOAc
  3. washwashed with brine
  4. dry with materialdried over MgSO4
  5. customevaporated

Sources & evidence

ORD record
ord-607f226fbe03428fad828a9b0e6e3ea5
Source dataset
uspto-grants-2001_04
Patent number
US06211184B1

Reaction notes

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