HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Dimethoxymethyl)-1,8-naphthyridine → 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Dimethoxymethyl)-1,8-naphthyridine | HCID 17750175 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine | HCID 17750176 | — |
Reaction Steps
A solution 14-1 (10 g, 0.049 mol) in MeOH, (100 ml) was treated with 10% Pd on C (1.5 g) and the resulting mixture stirred under a H2 filled balloon for 12.5 h. The catalyst was removed by filtration through celite and the solution concentrated to afford 14-2 as a yellow crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211184B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-399eb9738cbc4fabbd3d676239865ea1 |
| Source note | uspto-grants-2001_04 |