{6-Cyclopropyl-2-oxo-3-[(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-ylmethyl)-amino]-2H-pyridin-1-yl}-acetic acid → 3-(2-{6-Cyclopropyl-2-oxo-3-[(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-ylmethyl)-amino]-2H-pyridin-1-yl}-acetylamino)-3(S)-(3-fluorophenyl)-propionic acid ethyl ester

HRID 322541Notes

Reaction equation

HRID 322541 reaction equation
[CH:1]1([C:4]2[N:9]([CH2:10][C:11](O)=[O:12])[C:8](=[O:14])[C:7]([NH:15][CH2:16][C:17]3[CH:26]=[CH:25][C:24]4[CH2:23][CH2:22][CH2:21][NH:20][C:19]=4[N:18]=3)=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.Cl.[NH2:28][C@H:29]([C:36]1[CH:41]=[CH:40][CH:39]=[C:38]([F:42])[CH:37]=1)[CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32]>>[CH2:34]([O:33][C:31](=[O:32])[CH2:30][C@H:29]([NH:28][C:11](=[O:12])[CH2:10][N:9]1[C:4]([CH:1]2[CH2:3][CH2:2]2)=[CH:5][CH:6]=[C:7]([NH:15][CH2:16][C:17]2[CH:26]=[CH:25][C:24]3[CH2:23][CH2:22][CH2:21][NH:20][C:19]=3[N:18]=2)[C:8]1=[O:14])[C:36]1[CH:41]=[CH:40][CH:39]=[C:38]([F:42])[CH:37]=1)[CH3:35]

Participants

3

Procedure

Following the procedure described for the preparation of 16-5, the acid 17-7 was coupled with the amine 17-8 to yield the title compound 17-9.

Workup

  1. customdescribed for the preparation of 16-5

Sources & evidence

ORD record
ord-12098300e0eb42689fd6534f60ee2db2
Source dataset
uspto-grants-2001_04
Patent number
US06211184B1

Reaction notes

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