Glycine → HCID 178454190, compound

Participants

Reaction Steps

To a solution of Boc—(D)—Arg(Cbz2)—OSu (1 g, 1.6 mmol) in dioxane (10 mL) was added a solution of Gly (300 mg, 4 mmol) and NaHCO3 (400 mg, 4.76 mmol) in water (10 mL). The solution was stirred for 24 h. Solvents were evaporated and residue was dissolved in a mixture of EtOAc (20 mL) and 1 N HCl (6 mL). The separated organic layer was washed with sat. NaCl (10 mL), dried over MgSO4, filtered and evaporated to give a solid residue which was used directly without further purification. ES—MS (M+H)+=600

Provenance & Evidence