反应详情

The compound of Example 10 (300 mg, 0.47 mmol) was dissolved in 10 mL of MeOH and then 10% Pd/C (150 mg) was added. The reaction was hydrogenated under normal pressure overnight, filtered through Celite, rinsed with MeOH (3×10 mL) and concentrated in vacuo to give the desired compound (242 mg, 84%) which was used without further purification. ES—MS (M+H)+540.0

1. customwas hydrogenated under normal pressure overnight
2. filtrationfiltered through Celite
3. washrinsed with MeOH (3×10 mL)
4. concentrationconcentrated in vacuo