Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → (R,R)-N-[4-(3-trifluoromethylphenyl)-2-butyl]-1-(1-naphthyl)ethylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | (+)-1-(1-Naphthyl)ethylamine | HCID 2724264 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | 4-[3-(Trifluoromethyl)phenyl]butan-2-one | HCID 13339059 | — |
| 촉매 | Titanium isopropoxide | HCID 11026 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | (R,R)-N-[4-(3-trifluoromethylphenyl)-2-butyl]-1-(1-naphthyl)ethylamine | HCID 9951316 | — |
| 생성물 | (S,R)-N-[4-(3-trifluoromethylphenyl)-2-butyl]-1-(1-naphthyl)ethylamine | HCID 53733257 | — |
반응 단계
In a similar fashion an equal molar amount of 4-(3-trifluoromethylphenyl)-2-butanone, (R)-1-(1-naphthyl)ethylamine and 1.25 equivalents titanium(IV) isopropoxide were mixed and the intermediate imine reduced with ethanolic sodium cyanoborohydride. Work-up and repetitive preparative thin-layer chromatography using 5% methanol in chloroform afforded (S,R)-N-[4-(3-trifluoromethylphenyl)-2-butyl]-1-(1-naphthyl)ethylamine, 25C [m/z (rel. int.) 371 (M+, 3), 356 (16), 198 (15), 155 (100), 129 (8),115 (5),109 (3), 77 (2)] and (R,R)-N-[4-(3-trifluoromethylphenyl)-2-butyl]-1-(1-naphthyl)ethylamine, 25D; m/z (rel. int.) 371 (M+, 3), 356 (16), 198 (15), 155 (100), 129 (8), 115 (5), 109 (3), 77 (2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211244B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-b89a225fdf774d84bf1806a839a76f6f |
| 출처 메모 | uspto-grants-2001_04 |