反应详情

To a solution of 4-[4-methyl-2-(3,3,5,5-tetramethylcyclohexyl)phenyl]-1-propyl-1,2,3,6-tetrahydropyridine hydrochloride (50 mg, 0.13 mmol) produced in Example (104g) in methanol (10 mL) was added 10% palladium on carbon (50 mg, wet), followed by stirring for 2 hours at atmospheric pressure and room temperature under a hydrogen atmosphere. The reaction mixture was filtered through Celite, and the obtained filtrate was concentrated under reduced pressure. Hexane was added to the residue to produce a solid, which was then triturated by sonication. The solid was filtered and dried under reduced pressure to give 16 mg of the title compound as a light yellow solid.

1. filtrationThe reaction mixture was filtered through Celite
2. concentrationthe obtained filtrate was concentrated under reduced pressure
3. additionHexane was added to the residue
4. customto produce a solid, which
5. customwas then triturated by sonication
6. filtrationThe solid was filtered
7. customdried under reduced pressure