反应详情

4-Nitro-(2-Hydroxyethoxy)benzene (1.13 g, 6.2 mmol) in thionyl chloride (10 mL) is heated at reflux for 3 hours then concentrated in vacuo. After cooling the residue in an ice water bath, saturated aqueous sodium bicarbonate is added and the precipitate collected, rinsed with water, and dried to give 4-nitro-(2-chloroethoxy)benzene (909 mg).

1. temperatureat reflux for 3 hours
2. concentrationthen concentrated in vacuo
3. temperatureAfter cooling the residue in an ice water bath
4. additionsaturated aqueous sodium bicarbonate is added
5. customthe precipitate collected
6. washrinsed with water
7. customdried