反应详情

温度

60 °C

To a solution of 4cyclohexylbenzoic acid (Aldrich; 1 molar eq.) in toluene was added diisobutylaluminum hydride (Aldrich; 1 M in toluene; 4 molar eq.) over a 2 hour period. After addition was complete, the reaction was heated to 60° C. for 1 hour. The reaction was cooled to 5° C. and quenched with saturated aqueous ammonium chloride. The layers were separated and the aqueous layer extracted with ethyl acetate. The combined organics were filtered to remove salts and concentrated.

1. additionAfter addition
2. temperatureThe reaction was cooled to 5° C.
3. customquenched with saturated aqueous ammonium chloride
4. customThe layers were separated
5. extractionthe aqueous layer extracted with ethyl acetate
6. filtrationThe combined organics were filtered
7. customto remove salts
8. concentrationconcentrated