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HRID322706

反应详情

EQUATION

反应方程式

HRID 322706 的结构方程式

REACTANTS

反应物

3
结构：C[C@H](NC(=O)OC(C)(C)C)C(=O)O
HCID85082

L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-

C8H15NO4

结构：COC(=O)[C@@H](N)Cc1ccccc1
HCID736234

(+)-L-Phenylalanine methyl ester

C10H13NO2

结构：COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)N
HCID12988705

未命名化合物

PRODUCTS

生成物

1
结构：C=CCCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC
HCID9880679

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.ClCCl
溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

Following General Procedure A and using N-(L-alaninyl)-L-phenylalanine methyl ester (prepared by coupling N-BOC-L-alanine (Sigma) and L-phenylalanine methyl ester (Sigma) using General Procedure A, followed by removal of the BOC-group using General Procedure Y) and pent-4-enoic acid (Aldrich), the title compound was prepared as a solid (mp=125.5-126.5° C.). The reaction was monitored by tlc (Rf=0.32 in 50% EtOAc/hexanes; 0.51 in 10% CH3OH/CH2Cl2) and the product was purified by flash chromatography using 10% CH3OH/CH2Cl2 as the eluent.

WORKUP

后处理

  1. customprepared
  2. customfollowed by removal of the BOC-group
  3. customthe product was purified by flash chromatography