huagongshe.com
HRID322733

反应详情

EQUATION

反应方程式

HRID 322733 的结构方程式

REACTANTS

反应物

2
结构：C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O
HCID12135350

N-[(3,5-difluorophenyl)acetyl]alanine

C11H11F2NO3

结构：COC(=O)C1(N)CC1.Cl
HCID12760695

Methyl 1-aminocyclopropane-1-carboxylate--hydrogen chloride (1/1)

C5H10ClNO2

PRODUCTS

生成物

1
结构：COC(=O)C1(NC(=O)[C@H](C)NC(=O)Cc2cc(F)cc(F)c2)CC1
HCID9819300

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.ClC(Cl)Cl
溶剂HCID21584188

Chloroform methanol

C2H5Cl3O

PROCEDURE

实验过程

Following General Procedure C and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl 1-aminocyclopropane-1-carboxylate hydrochloride (Sigma), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.3 in 95:5 CHCl3/MeOH) and the product was purified by silica gel chromatography using 97:3 CHCl3/MeOH as the eluent.

WORKUP

后处理

  1. customthe product was purified by silica gel chromatography