HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl tryptophanate hydrochloride → N-(N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-tryptophan Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl tryptophanate hydrochloride | HCID 2734891 | — |
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | N-(N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-tryptophan Methyl Ester | HCID 22894900 | — |
Reaction Steps
Following General Procedure C and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and L-tryptophan methyl ester hydrochloride (Sigma), the title compound was prepared as a solid (mp=191-193° C.). The reaction was monitored by tlc (Rf=0.4 in 10% MeOH/CHCl3) and the product was purified by silica gel chromatography using 5% MeOH/CHCl3 as the eluent, followed by recrystallization from 1-chlorobutane/acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211235B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-dd5fefba19f44cfa9be8674d8c2cb7be |
| Source note | uspto-grants-2001_04 |