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Tert-butoxycarbonylalanine → HCID 22894895、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tert-butoxycarbonylalanine | HCID 85082 | — |
| 反応物 | 3,5-Difluorophenylacetic acid | HCID 145424 | — |
| 反応物 | L-Phenylalanine, 1,1-dimethylethyl ester, hydrochloride (1:1) | HCID 11459563 | — |
| 反応物 | HCID 69622800 | HCID 69622800 | — |
| 溶媒 | Chloroform methanol | HCID 21584188 | — |
| 生成物 | HCID 22894895 | HCID 22894895 | — |
反応手順
Following General Procedure C and using 3,5-difluorophenylacetic acid (Oakwood) and N-(L-alaninyl)-L-phenylalanine tert-butyl ester hydrochloride (prepared from N-BOC-L-alanine (Sigma) and L-phenylalanine tert-butyl ester hydrochloride (Advanced Chemtech) using General Procedure C, followed by removal of the BOC-group using General Procedure P), the title compound was prepared as a gel. The reaction was monitored by tlc (Rf=0.5 in 4% MeOH/CHCl3) and the product was purified by silica gel chromatography using 4% MeOH/CHCl3 as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211235B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-d66359f7d9d14509b5bfb59e600dd259 |
| 出典メモ | uspto-grants-2001_04 |