Methyl valinate hydrochloride → HCID 22895053, compound

HRID 322781Notes

Reaction equation

HRID 322781 reaction equation
[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:13]([OH:15])=O)[CH3:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:17][O:18][C:19](=[O:25])[C@H:20]([CH:22]([CH3:24])[CH3:23])[NH2:21]>>[CH3:17][O:18][C:19](=[O:25])[C@H:20]([CH:22]([CH3:24])[CH3:23])[NH:21][C:13](=[O:15])[C@H:11]([CH3:12])[NH:10][C:8](=[O:9])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 111190Methyl valinate hydrochlorideHCID 7004640N-(Phenylacetyl)-L-alanine

Product 1

HCID 22895053HCID 22895053, compound

Procedure

Following General Procedure A and using N-(phenylacetyl)-L-alanine (fromo Example B1 above) and L-valine methyl ester hydrochloride (Aldrich), the title compound was prepared as a solid (mp=112-115° C.). The reaction was monitored by tlc (Rf=0.33 in 50% EtOAc/hexanes) and the product was not purified.

Workup

  1. customthe product was not purified

Sources & evidence

ORD record
ord-971657953f834f3590d7547eda4bb7d1
Source dataset
uspto-grants-2001_04
Patent number
US06211235B1

Reaction notes

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