Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Salicylic acid, 4-nitro-, methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 4-Nitrosalicylic acid | HCID 69266 | — |
| 반응물 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | Salicylic acid, 4-nitro-, methyl ester | HCID 139539 | 100% |
반응 단계
916 mg (5 mmol) of 2-hydroxy-4-nitro-benzoic acid is dissolved in a mixture that consists of 8 ml of methanol and 32 ml of toluene, and it is slowly mixed with a solution of trimethylsilyldiazomethane in hexane (2 molar). After the addition is completed, stirring is continued for 1.25 hours at room temperature. After the reaction mixture is concentrated by evaporation, 1 g (about 100% of theory) of 2-hydroxy-4-nitro-benzoic acid methyl ester is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07427390B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-f4482a156b1b490eac5d912bb108e093 |
| 출처 메모 | uspto-grants-2008_09 |