Hydrochloric Acid → HCID 10551523, compound

Participants

Reaction Steps

A mixture of ethyl (E)-2-benzyl-3-(2,4-dibenzyloxyphenyl)acrylate (1.5 g) and aqueous potassium hydroxide in methanol (50 mL, 15%) is stirred and heated at reflux for 3 hours. The reaction mixture is diluted with water (30 mL) plus 3 N potassium hydroxide solution (5 mL), acidified to pH 1 by addition of concentrated hydrochloric acid and the resulting solid filtered. Recrystallisation from a mixture of ethyl acetate and pentane gives E-2-benzyl-3-(2,4-dibenzyloxyphenyl)acrylic acid (1.13 g) as a white solid, m.p. 175-176° C. [Elemental analysis:- C,79.7; H,5.72%. Calculated:- C,80.0; H,5.82%].

Provenance & Evidence