Potassium Hydroxide → HCID 10621058, compound

Participants

Reaction Steps

A solution of ethyl 3-(2,4-dibenzyloxyphenyl)isoxazole-5-carboxylate (2.2 g) in hot methanol (100 mL) is treated with 10% aqueous potassium hydroxide solution (10 mL w/v) and the mixture is heated to reflux for 2 hours. The reaction mixture is evaporated to low bulk, stirred with 1 N hydrochloric acid (50 mL) for 15 minutes and filtered. The resulting solid is washed with water, dried and crystallised from ethyl acetate to give 3-(2,4-dibenzyloxyphenyl)isoxazole-5-carboxylic acid (1 g), in the form of a white solid, m.p. 192-193° C. [Elemental analysis:- C,71.7; H,4.67; N,3.34%. Calculated:- C,71.8; H,4.77; N,3.49%].

Provenance & Evidence