HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-Amino-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 4-nitro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide | HCID 408891 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Amino-N-[2-(diethylamino)ethyl]-2-methoxybenzamide | HCID 77374 | 106.4% |
Reaction Steps
5.7 g (19.3 mmol) of 4-nitro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide is dissolved in 120 ml of tetrahydrofuran:ethanol=1:1, mixed with 2 g of palladium on carbon (10%×50% water) and hydrogenated for 1 hour at room temperature and normal pressure. After being drawn off on diatomaceous earth and after concentration by evaporation, 5.45 g of 4-amino-N-(2-diethylamino-ethyl)-2-methoxy-benzamide is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427390B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-a4a84b761f37465986edb7e193759a3c |
| Source note | uspto-grants-2008_09 |