反应详情

A stirred solution of benzyl 2-benzyloxy-4-phenylethynylbenzoate (2 g) and 1 N sodium hydroxide (5 mL) in dioxan (80 mL) is heated at reflux for 1 hour. The reaction mixture is evaporated, the residue dissolved in water (6 mL) and the solution washed twice with ethyl acetate (20 mL). The pH of the aqueous phase is adjusted to pH 1 by addition of 2 N hydrochloric acid and resulting solid is filtered and washed well with water to give 2-benzyloxy-4-phenylethynylbenzoic acid (0.6 g), m.p. 125-127° C. [Elemental analysis:- C,80.2; H,4.86%. Calculated:- C,80.5; H,4.91%].

1. temperatureat reflux for 1 hour
2. customThe reaction mixture is evaporated
3. dissolutionthe residue dissolved in water (6 mL)
4. washthe solution washed twice with ethyl acetate (20 mL)
5. additionThe pH of the aqueous phase is adjusted to pH 1 by addition of 2 N hydrochloric acid
6. customresulting solid
7. filtrationis filtered
8. washwashed well with water