反应详情

A mixture of ethyl (RS)-4-(3-benzyloxy-phenoxy)-4-phenylbutanoate (1 g), aqueous potassium hydroxide solution (5 mL;10% w/v) and methanol (50 mL) is stirred at reflux for 30 minutes. The reaction mixture is then evaporated to dryness and the residue is partitioned between ethyl acetate (100 mL) and dilute hydrochloric acid (50 mL; 1 N). The organic layer is washed with water, dried over magnesium sulphate, filtered and concentrated under reduced pressure to give a brown oil, which slowly crystallises. Recrystallisation from cyclohexane gives (RS)-4-(3-benzyloxyphenoxy)-4-phenylbutanoic acid (0.55 g), in the form of a beige solid, m.p. 100-104° C. [Elemental analysis:- C,76.3;H,6.21%; Calculated:- C,76.2;H,6.12%].

1. temperatureat reflux for 30 minutes
2. customThe reaction mixture is then evaporated to dryness
3. customthe residue is partitioned between ethyl acetate (100 mL) and dilute hydrochloric acid (50 mL; 1 N)
4. washThe organic layer is washed with water
5. dry with materialdried over magnesium sulphate
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure
8. customto give a brown oil, which
9. customslowly crystallises
10. customRecrystallisation from cyclohexane