Lawesson's reagent → HCID 10552280, compound

Participants

Reaction Conditions

Reaction Steps

A stirred solution of ethyl (RS)-4-[2-carbamoyl-5-(3-thienylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate (2.44 g) in tetrahydrofuran (49 mL) is treated with 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulphide (1.08 g) and maintained at 25° C. for 24 hours. The solution is then evaporated and the residual oil is subjected to flash chromatography on silica gel, eluting with a mixture of pentane and ethyl acetate (2:1 v/v), followed by trituration with diethyl ether, to give ethyl (RS)-4-(2-methylphenyl)-4-[5-(3-thienylmethoxy)-2-thiocarbamoylphenoxy]butanoate (1.79 g) in the form of a yellow solid, m.p. 134-135° C. [NMR(CDCl3):- 1.2(3H,t),2.2-2.6(4H,m), 2.4(3H,s),4.1(2H,q), 4.9(2H,q),5.6(1H,m),6.2-7.8(9H,m),8.7(1H,d)].

Provenance & Evidence