Acetone → HCID 86756584, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl (RS)-4-(2-methylphenyl)-4-[2-methylthio-5-(3-thienylmethoxy)phenoxy]butanoate in acetone (20 mL), at 0° C. is treated dropwise with a solution of potassium peroxymonosulphate (1.01 g of commercial 2KHSO5:KHSO4:K2SO4). The reaction mixture is stirred at 0° C. for 20 minutes, then treated with saturated aqueous sodium bisulphate solution (20 mL), and extracted with dichloromethane (2×50 mL). The combined organic extracts are dried over magnesium sulphate, filtered and concentrated in vacuo, to give ethyl (RS,RS)-4-(2-methylphenyl)-4-[2-methyl-sulphinyl-5-(3-thienylmethoxy)phenoxy)-butanoate (0.75 g) in the form of a yellow oil.

Provenance & Evidence