HRID322891

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7582

Dicyclohexylamine

C12H23N

结构：Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2cccnc2)ccc1C#N

HCID22010149

未命名化合物

PRODUCTS

生成物

结构：C1CCC([NH2+]C2CCCCC2)CC1.Cc1ccccc1C(CCC(=O)[O-])Oc1cc(OCc2cccnc2)ccc1C#N

HCID22010329

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

A mixture of 4-[2-cyano-5-(3-pyridylmethoxy)-phenoxy]-4-(2-methylphenyl)butanoic acid, thought to be the (R)-enantiomer, (50 mg), dicyclohexylamine (0.5 mL) and diethyl ether (10 mL) is stirred at ambient temperature for 18 hours. The resulting precipitate is collected and washed with diethyl ether, to give dicyclohexylammonium 4-[2-cyano-5-(3-pyridylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate, thought to be the (R)-enantiomer, (30 mg) in the form of a white solid, m.p. 92-93° C.

WORKUP

后处理

customThe resulting precipitate is collected
washwashed with diethyl ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d77ef45c1c564a5cb061d24f48a0d56d
来源数据集: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06211234B1
来源说明: uspto-grants-2001_04

反应 SMILES

[C:1]([C:3]1[CH:22]=[CH:21][C:20]([O:23][CH2:24][C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)=[CH:19][C:4]=1[O:5][CH:6]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH3:18])[CH2:7][CH2:8][C:9]([OH:11])=[O:10])#[N:2].[CH:31]1([NH:37][CH:38]2[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>C(OCC)C>[C:1]([C:3]1[CH:22]=[CH:21][C:20]([O:23][CH2:24][C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)=[CH:19][C:4]=1[O:5][CH:6]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH3:18])[CH2:7][CH2:8][C:9]([O-:11])=[O:10])#[N:2].[CH:38]1([NH2+:37][CH:31]2[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]2)[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]1