Hydrochloric Acid → HCID 23204195, compound

Participants

Reaction Steps

A solution of ethyl (RS)-4-[(2-acetyl-5-(3-thienylmethoxy)-phenoxy]-4-(2-cyanophenyl)butanoate (250 mg) in methanol (10 ml) containing 1N sodium hydroxide (3 mL) is stirred at ambient temperature for 16 hours. The reaction mixture is poured into 0.5 N hydrochloric acid (20 mL) and extracted twice with ethyl acetate (20 mL). The combined organic phases are washed with brine (20 mL), dried over magnesium sulphate and concentrated under reduced pressure to leave a dark yellow oil. Crystallization from a mixture of cyclohexane and ethyl acetate affords (RS)-4-[(2-acetyl-5-(3-thienylmethoxy)phenoxy]-4-(2-cyanophenyl)butanoic acid (20 mg) in the form of a beige solid, m.p. 132-134° C. [Elemental analysis:- C, 66.0, H, 4.87, N, 3.02%. Calculated:- C, 66.2, H, 4.86, N, 3.22%].

Provenance & Evidence