反应详情

A mixture of 2-fluoro-4-(3-thienylmethoxy)nitrobenzene (4.21 g), aqueous potassium hydroxide solution (50 mL; 50% w/v) and t-butanol (20 mL) is heated at reflux for 4 hours. It is then evaporated to dryness and the residue is partitioned between ethyl acetate (100 mL) and hydrochloric acid (100 mL; 1 N). The organic phase is washed with water (3×100 mL), dried over magnesium sulphate, filtered and evaporated, to give 2-nitro-5-(3-thienylmethoxy)phenol, in the form of a yellow solid.

1. temperatureis heated
2. temperatureat reflux for 4 hours
3. customIt is then evaporated to dryness
4. customthe residue is partitioned between ethyl acetate (100 mL) and hydrochloric acid (100 mL; 1 N)
5. washThe organic phase is washed with water (3×100 mL)
6. dry with materialdried over magnesium sulphate
7. filtrationfiltered
8. customevaporated