反应详情

A solution of ethyl (RS)-4-[2-(4,5-dihydrooxazol-2-yl)-5- (3-thienylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate (900 mg) and nickel peroxide (5.04 g) in toluene (50 mL) is stirred at 100° C. for 2 hours. The reaction is left at ambient temperature for 16 hours then filtered through a pad of hyflo and the filtrate concentrated in vacuo. The residue is purified by flash chromatography on silica eluting with a mixture of ethyl acetate and cyclohexane (15:85 v/v). Fractions homogeneous in the required product are combined and evaporated to give ethyl (RS)-4-[2-(oxazol-2-yl)-5-(3-thienylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate (140 mg) and starting material (400 mg).

1. filtrationthen filtered through a pad of hyflo
2. concentrationthe filtrate concentrated in vacuo
3. customThe residue is purified by flash chromatography on silica eluting with a mixture of ethyl acetate and cyclohexane (15:85 v/v)
4. customevaporated