2-Ethylphenyl isocyanate → N-(2-hydroxy-4-nitrophenyl)-N'-(2-ethylphenyl)urea

Participants

Role	Name	HCID	Charge
Reactant	2-Ethylphenyl isocyanate	HCID 583486	—
Reactant	2-Amino-5-Nitrophenol	HCID 4984721	—
Product	N-(2-hydroxy-4-nitrophenyl)-N'-(2-ethylphenyl)urea	HCID 21184795	45.1%

Reaction Steps

N-(2-Hydroxy-4-nitrophenyl)-N′-(2-ethylphenyl)urea was prepared from 2-hydroxy 4nitro aniline (500 mg, 3.24 mmol) and 2-ethyl phenyl isocyanate (3.24 mmol) according to the procedure in General Method B. The product was purified by dilution with methylene chloride and precipitation with hexanes. Filtering afforded the title compound (0.44 g, 43%). EI-MS m/z 302 (M+H)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06211373B1
Source dataset	uspto-grants-2001_04
ORD ID	ord-28c1db5b601d457290922637d4c8de57
Source note	uspto-grants-2001_04