2-Tolyl isocyanate → HCID 22011319, compound

HRID 323056Notes

Reaction equation

HRID 323056 reaction equation
[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]=[C:20]=[O:21]>>[OH:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:20]([NH:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[CH3:12])=[O:21]

Participants

3

Reactant 2

HCID 691942-Tolyl isocyanateHCID 49847212-Amino-5-Nitrophenol

Product 1

HCID 22011319HCID 22011319, compoundYield 66.1%

Procedure

The urea was prepared from 2-hydroxy 4-nitro aniline (308 mg, 2 mmol) and 2-methyl phenyl isocyanate (2 mmol) by general Method B. It was purified by dilution with methylene chloride and precipitation with hexane. Filtering afforded the title compound (0.38 g, 53%). EI-MS m/z 288 (M+H)+

Workup

  1. customIt was purified by dilution with methylene chloride and precipitation with hexane
  2. filtrationFiltering

Sources & evidence

ORD record
ord-d3812fa618d648e09dd19eb14e68f348
Source dataset
uspto-grants-2001_04
Patent number
US06211373B1

Reaction notes

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