2-Bromophenyl isocyanate → HCID 53805601, compound

HRID 323114Notes

Reaction equation

[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([S:13]([NH:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[NH2:19])(=[O:15])=[O:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[Br:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[N:33]=[C:34]=[O:35]>>[F:10][C:9]([F:11])([F:12])[C:7]1[CH:6]=[C:5]([S:13]([NH:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[NH:19][C:34]([NH:33][C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[Br:26])=[O:35])(=[O:14])=[O:15])[CH:4]=[C:3]([C:2]([F:24])([F:1])[F:25])[CH:8]=1

Participants

Reactant 2

HCID 1370972-Bromophenyl isocyanate

HCID 3476927HCID 3476927, compound

Product 1

HCID 53805601HCID 53805601, compound

Procedure

The title compound was prepared from [2-(3,5-bistrifluoromethylphenyl) sulfonylaminoaniline (591 mg, 1.5 mmol) and 2-bromophenylisocyanate (305 mg, 1.5 mmol) according to General Method B. The product was purified by flash chromatography on silica gel (ethyl acetate:hexane 30/70) (10 mg, 1%). EI-MS m/z 580 (M−H)−.

Workup

customThe product was purified by flash chromatography on silica gel (ethyl acetate:hexane 30/70) (10 mg, 1%)

Sources & evidence

ORD record: ord-1195c83b93b14dcdb1e41388432f9169
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211373B1

Reaction notes

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