Diethyl Ether → HCID 22010989, compound

Participants

Reaction Steps

To a solution of 2-ethoxycarbonyl-N-(4-nitrobenzoyl)aniline (3.15 g) in N,N-dimethylformamide (30 ml) was added sodium hydride (60% in oil, 442 mg) and the solution was stirred at ambient temperature for 30 minutes. Iodomethane (1.56 g) was added to the solution and the mixture was stirred at ambient temperature for 4 hours. The solution was diluted with ethyl acetate and the solution was washed with successively with 1N hydrochloric acid, water and brine. The organic phase was dried over magnesium sulfate and the solvent was evaporated in vacuo to give an oil. The oil was solidified with diethyl ether to give 2-ethoxycarbonyl-N-methyl-N-(4-nitrobenzoyl)aniline (3.28 g) as a pale yellow powder.

Provenance & Evidence