Diethyl Ether → HCID 22010687, compound

Participants

Reaction Steps

To a solution of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-benzoyloxyphenyl)benzamide (350 mg) in methanol (10 ml) was added potassium carbonate (89.5 mg) and the mixture was stirred at ambient temperature overnight. Chloroform was added to the mixture and the solution was washed with water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give an oil and the oil was subjected to silica gel column (30 g, 1% methanol in chloroform) to give an oil. The oil was solidified with diethyl ether to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-hydroxyphenyl)benzamide (228 mg) as a white powder.

Provenance & Evidence