HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 22010563, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 22010892 | HCID 22010892 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 22010563 | HCID 22010563 | 98.5% |
Reaction Steps
A mixture of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-(3-phthalimidopropyloxy)phenyl]benzamide (545 mg) and hydrazine hydrate (0.212 ml) in ethanol (20 ml) was refluxed for 4 hours. After removal of insoluble material, the filtrate was evaporated in vacuo to give an oil and the oil was subjected to a silica gel column (5% methanol in chloroform) to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-(3-aminopropyloxy)phenyl]benzamide (425 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211242B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-380f2ee1c30f42aab2fd6148563789f2 |
| Source note | uspto-grants-2001_04 |