反应详情

A solution of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-(5-carboxy-1-pentenyl)phenyl]benzamide (150 mg) in ethanol (10 ml) was shaken under hydrogen atmosphere (3 atm.) in the presence of 10% palladium on carbon (50 mg) for 4 hours. The catalyst was filtered off and the filtrate was evaporated in vacuo and the residue was subjected to silica gel column (29% methanol in chloroform) to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-(5-carboxypentyl)phenyl]benzamide (150 mg).

1. filtrationThe catalyst was filtered off
2. customthe filtrate was evaporated in vacuo