Chloroform → HCID 22010844, compound

Participants

Reaction Steps

To a solution of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-acetylphenyl)benzamide (200 mg) in methanol (15 ml) was added sodium borohydride (16.4 mg) and the solution was stirred at ambient temperature for 3 hours. Chloroform was added to the mixture and the solution was washed successively with water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give a syrup and the crude product was purified by silica gel column (chloroform) to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-(1-hydroxyethyl)phenyl]-benzamide (150 mg) as a white solid.

Provenance & Evidence