反应详情

A mixture of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-hydroxymethylphenyl)benzamide (100 mg) and acetic anhydride (34 mg) in pyridine (5 ml) was stirred at ambient temperature for 3 days and the solvent was evaporated in vacuo. The residue was dissolved in chloroform and the organic solution was washed successively with 1N hydrochloric acid, water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give an oil and the oil was solidified with diethyl ether to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-acetoxymethylphenyl)benzamide (105 mg) as a white powder.

1. customthe solvent was evaporated in vacuo
2. dissolutionThe residue was dissolved in chloroform
3. washthe organic solution was washed successively with 1N hydrochloric acid, water and brine
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated in vacuo
6. customto give an oil