Ethyl Acetate → HCID 22011022, compound

Participants

Reaction Steps

To a solution of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-carboxymethoxyphenyl)benzamide (295 mg), N-methylpiperazine (60 mg) and 1-hydroxybenzotriazole hydrate (97 mg) in N,N-dimethylformamide (5 ml) was added N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (137 mg) at 0° C. and the mixture was stirred at ambient temperature for 15 hours. The resulting mixture was diluted with ethyl acetate and then the organic layer was washed successively with saturated sodium bicarbonate aqueous solution and brine. Drying, filtering and removal of solvents afforded a crude product. The crude product was chromatographed on silica gel (eluent; 3% methanol in chloroform) to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-(4-methyl-1-piperazinyl)carbonylmethoxyphenyl]benzamide (213 mg) as a white powder.

Provenance & Evidence