1,4-Dibromobutane → HCID 22010768, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4′-methylbiphenyl-2-carboxamido-N-methyl-N-(2-hydroxyphenyl)benzamide (750 mg) in N,N-dimethylformamide (35 ml) was added potassium carbonate (1.42 g), 1,4-dibromobutane (1.11 g). The reaction mixture was stirred at 60° C. for 3 hours and to this mixture containing 4′-methylbiphenyl-2-carboxamido-N-methyl-N-[2-(4-bromobutoxy)phenyl]benzamide was added 1-methylpiperazine (1.03 g) and stirring was continued additional 15 hours. The mixture was extracted with ethyl acetate and washed with water and brine. The organic solution was dried over sodium sulfate. The solvent was removed by evaporation and purified by silica gel column chromatography (SiO2; 35 g, 5% methanol in dichloromethane) to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-[4-(4-methylpiperazin-1-yl)butoxy]phenyl]benzamide.

Provenance & Evidence