HCID 2574890, compound → HCID 22010586, compound

Participants

Reaction Steps

To a mixture of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-(formylmethoxy)phenyl]benzamide (400 mg) and 4-methyl-1-(N-methylamino)methylcarbonylpiperazine (143 mg) in a mixture of methanol (15 ml) and acetic acid (0.5 ml) was added sodium cyanoborohydride (52.4 mg) and the mixture was stirred at ambient temperature for 4 hours. The solution was diluted with ethyl acetate (30 ml) and washed successively with saturated aqueous sodium hydrogen carbonate, water and brine. The organic solution was dried over magnesium sulfate and the solvent was evaporated in vacuo. The residue was purified by silica gel column (chloroform:methanol:conc. ammonia=10:1:0.1) to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-[2-[2-[N-methyl-N-(4-methylpiperazin-1-yl)carbonylmethylamino]ethoxy]phenyl]benzamide (310 mg) as a colorless amorphous.

Provenance & Evidence