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Methanol → (1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | (1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(1-benzylpiperidin-4-yl)amine | HCID 13808349 | — |
| 触媒 | Palladium hydrate | HCID 23219155 | — |
| 溶媒 | Triethylamine methanol | HCID 22728368 | — |
| 生成物 | (1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine | HCID 13808350 | — |
反応手順
Combine (1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(1-benzylpiperidin-4-yl)amine (0.51 g, 1.35 mmol), 20% palladium hydroxide-on-carbon, and methanol (40 mL). Hydrogenate in a Parr apparatus at an initial pressure of 40 psi. After 24 hours, filter through celite, rinse with methanol, and evaporate in vacuo to obtain a residue. Chromatograph the residue on silica gel eluting with 4% triethylamine/methanol to give the title compound: Rf=0.28 (2% triethylamine/methanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211199B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-43ddb64bf073452cbda6993d69b3f918 |
| 出典メモ | uspto-grants-2001_04 |