Diethyl Ether → (r)-1-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-methyl-1h-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dichlorophenyl)pyrrolidine methanesulfonic acid salt

Participants

Reaction Steps

Combine (R)-1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-methyl-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dichlorophenyl)pyrrolidine (0.3 g) and ethyl acetate (10 mL). Add dropwise, a solution of methanesulfonic acid (0.11 g, 1.1 mmol) in ethyl acetate (2 mL). Evaporate in vacuo to give a residue. Combine the residue and isopropanol (5 mL) and diethyl ether (200 mL). After 18 hours, a solid is obtained. Decant the supernatant and add diethyl ether. Collect the solid and dry in vacuo to give the title compound: mp; 146-160° C.

Provenance & Evidence