Diethyl Ether → 1-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1h-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(phenylmethyl)pyrrolidine methanesulfonic acid salt

Participants

Reaction Steps

Combine 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(phenylmethyl)pyrrolidine (0.45 g, 0.67 mmol) and methanesulfonic acid (0.14 g, 1.4 mmol) in ethyl acetate (5 mL). Heat to reflux. After 1 hour, allow to cool to ambient temperature. After 12 hours, add diethyl ether to give a solid. Collect the solid by filtration to give, after drying, the title compound.

Provenance & Evidence