Methanol → 1-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(4-fluorobenzyl)-1h-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dichlorophenyl)piperidine methanesulfonic acid salt

Participants

Reaction Steps

Combine 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(4-fluorobenzyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-dichlorophenyl)piperidine (0.54 g) and ethyl acetate (20 mL). Add a solution of methanesulfonic acid (0.14 g) in ethyl acetate (3 mL). After 1 hour concentrate in vacuo to give a residue. Combine the residue and methanol (10 mL) and add diethyl ether (200 mL) to obtain a residue. Decant the supernatant and add diethyl ether to obtain a solid. Collect the solid and dry to give the title compound. HRMS (FAB+): calculated 753.364711. Found 753.366354.

Provenance & Evidence