Methanesulfonic Acid → HCID 88072343, compound

Participants

Reaction Steps

Combine 1-(3,4,5-trimethoxybenzyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(4-methoxyphenylmethyl)-2-oxopyrrolidine (0.81 g, 1.16 mmol) and ethyl acetate. Add methanesulfonic acid (0.23 g, 2.44 mmol) and heat to reflux. After 1 hour, cool to ambient temperature. After 18 hours, add diethyl ether (100 mL) and stir to give a solid. Decant the supernatant, collect the solid, and dry to give the title compound: mp: 222-224° C.

Provenance & Evidence