2-Chloro-5-(chloromethyl)thiophene → 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(5-chlorothien-2-ylmethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl) Pyrrolidine

Participants

Reaction Steps

Prepare by the method of Example 37.2 using 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl) pyrrolidine and 5-chloro-2-(chloromethyl)thiophene to give, after purification on silica gel eluting with 1/2 methanol/ethyl acetate, the title compound: mp; 110-120° C. Rf=0.40 (silica gel, 1/2 methanol/ethyl acetate).

Provenance & Evidence