Hydrochloric Acid → HCID 22009041, compound

Participants

Reaction Steps

Combine 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(2-oxobutyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl)pyrrolidine (1.38 g) and methanol (100 mL). Add a solution of hydrochloric acid (1.90 mL, 4 M in dioxane) and stir. After 18 hour, evaporate in vacuo to give a residue. Combine the residue and methanol (5 mL) and stir rapidly. Add diethyl ether (200 mL). After 2 hours, decant the solvent and add diethyl ether. After 18 hours, collect the solid and dry in vacuo at 65° C. to give the title compound: mp; 180-184° C.

Provenance & Evidence