(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine → 1-(2-(3-carboethoxypropyloxy)-5-(1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine

HRID 323370Notes

Reaction equation

HRID 323370 reaction equation
[C:1]([CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:35]=[CH:34][C:33]([N:36]2[CH:40]=[N:39][N:38]=[N:37]2)=[CH:32][C:11]=1[C:12]([N:14]1[CH2:18][CH2:17][C:16]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)([CH2:19][CH2:20]OS(C)(=O)=O)[CH2:15]1)=[O:13])([O:3][CH2:4][CH3:5])=[O:2].[CH2:41]([O:43][CH2:44][CH2:45][N:46]1[C:50]2[CH:51]=[CH:52][CH:53]=[CH:54][C:49]=2[N:48]=[C:47]1[NH:55][CH:56]1[CH2:61][CH2:60][NH:59][CH2:58][CH2:57]1)[CH3:42]>>[C:1]([CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:35]=[CH:34][C:33]([N:36]2[CH:40]=[N:39][N:38]=[N:37]2)=[CH:32][C:11]=1[C:12]([N:14]1[CH2:18][CH2:17][C:16]([CH2:19][CH2:20][N:59]2[CH2:58][CH2:57][CH:56]([NH:55][C:47]3[N:46]([CH2:45][CH2:44][O:43][CH2:41][CH3:42])[C:50]4[CH:51]=[CH:52][CH:53]=[CH:54][C:49]=4[N:48]=3)[CH2:61][CH2:60]2)([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:15]1)=[O:13])([O:3][CH2:4][CH3:5])=[O:2]

Participants

3

Reactant 2

HCID 13808350(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amineHCID 184650481-(2-(3-carboethoxypropyloxy)-5-(1H-tetrazol-1-yl)benzoyl)-3-phenyl-3-(2-methanesulfonyloxyethyl)pyrrolidine

Product 1

HCID 220094981-(2-(3-carboethoxypropyloxy)-5-(1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine

Procedure

Prepare by the method of Example 1.6 using 1-(2-(3-carboethoxypropyloxy)-5-(1H-tetrazol-1-yl)benzoyl)-3-phenyl-3-(2-methanesulfonyloxyethyl)pyrrolidine and (1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine to give the title compound.

Sources & evidence

ORD record
ord-763354fdcd824eababdc14caffb03606
Source dataset
uspto-grants-2001_04
Patent number
US06211199B1

Reaction notes

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